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ea0049ep7 | Adrenal cortex (to include Cushing's) | ECE2017

Molecular variability determines subtle adrenal biosynthetic defect in non-classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency

Mermejo Livia , Coeli-Lacchini Fernanda , Turatti Wendy , Elamid Marcia , Parente Renata , Martinelli Carlos , Antonini Sonir , Castro Margaret , Moreira Ayrton

There is a clinical spectrum of non-classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency (NC-CAH). In addition, CYP21A2 gene mutations analysis present in homozygosis or as compound heterozygosis.Objectives: To evaluate the relationship between the genotype and biochemical profiles and also compare with clinical severity in NC-CAH.Patients and methods: Clinical, hormonal and molecular data of 57 patien...

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ea0070aep48 | Adrenal and Cardiovascular Endocrinology | ECE2020

Early renin recovery after adrenalectomy in patients with aldosterone-producing adenoma - a longitudinal study.

Mermejo Livia M , Elias Paula CL , Molina Carlos AF , Tucci Silvio , Antonini Sonir R , Castro Margaret , Moreira Ayrton

Background: Low plasma aldosterone after adrenalectomy due to aldosterone-producing adenoma (APA) and postoperative hypoaldosteronism recovery have been well described. However, prospective time course comparing simultaneously aldosterone and renin levels is still lacking.Aim: We prospectively studied clinical and biochemical findings emphasizing aldosterone and renin levels, in a cohort of patients with APA who underwent adrenalectomy in a single tertia...

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Endocrine Abstracts

Molecular variability determines subtle adrenal biosynthetic defect in non-classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency

Early renin recovery after adrenalectomy in patients with aldosterone-producing adenoma - a longitudinal study.

BiosciAbstracts